Mechanisms mediating caspase activation in cell death
نویسندگان
چکیده
منابع مشابه
Signalling mechanisms mediating Zn2+-induced TRPM2 channel activation and cell death in microglial cells
Excessive Zn2+ causes brain damage via promoting ROS generation. Here we investigated the role of ROS-sensitive TRPM2 channel in H2O2/Zn2+-induced Ca2+ signalling and cell death in microglial cells. H2O2/Zn2+ induced concentration-dependent increases in cytosolic Ca2+ concentration ([Ca2+]c), which was inhibited by PJ34, a PARP inhibitor, and abolished by TRPM2 knockout (TRPM2-KO). Pathological...
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Recent work has shown that execution of the apoptotic program involves a relatively limited number of pathways. According to a general view, these would converge to activate the caspase family of proteases. However, there is increasing evidence that apoptotic-like features can be found also when cells are treated with inhibitors of caspases as the cell permeable tripeptide, Z-Val-Ala-Asp-fluoro...
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Caspase-mediated apoptosis is the death program of choice in many developmental and physiologic settings (Kerr et al., 1972; Strasser et al., 2000; Kaufmann and Hengartner, 2001). It would, however, be very dangerous for the organism to depend on a single protease family for clearance of unwanted and potentially dangerous cells. Indeed, the exclusive role of caspases in the execution of program...
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During programmed cell death (PCD) apoptosis is controlled by many factors such as proteases. With no specific protease (s) known during PCD in the developing nervous system so far, we sought to determine if any specific protease (s) is involved in this process and therefore used different protease inhibitors during PCD (from embryonic day 6 to 10) in chick embryos. Among the inhibitors commerc...
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ژورنال
عنوان ژورنال: Cell Death & Differentiation
سال: 1999
ISSN: 1350-9047,1476-5403
DOI: 10.1038/sj.cdd.4400600